Cytokine concentrations throughout pregnancy and risk for psychosis in adult offspring: a longitudinal case-control study.

ABSTRACT:

Background

Schizophrenia has been associated with pregnancy and birth complications and fetal exposure to inflammation is thought to be a common underlying mechanism. However, whether the risk is specific to particular phases of pregnancy is unclear. The aim of this study was to characterise and compare longitudinal patterns of maternal serum concentrations of cytokines across pregnancy between offspring who were later ascertained to have a psychotic disorder, non-psychotic siblings of these cases, and unrelated, non-psychotic individuals who served as controls.

Methods

The National Collaborative Perinatal Project was a large-scale prospective longitudinal study that assessed the effects of perinatal factors on infant and child development. At sites across the USA, over 50 0

SUBMITTER: Allswede DM 

PROVIDER: S-EPMC8287973 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature