Proteomics

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Gestational chronodisruption throughout pregnancy impairs adipose tissue physiology in the offspring

ABSTRACT: Compelling evidence supports that gestational chronodisruption induces major changes in maternal circadian rhythms, fetal development and that these changes impact adult life at many physiological levels. Using a rat model of chronic photoperiod shifting throughout gestation (CPS), we investigated the detrimental effects of gestational CPS on glucose homeostasis, adipose tissue physiology and metabolism in the adult male offspring. At proteomic level, in CPS adipose tissue, 275 proteins displayed differential expression, compared with LD animals fed with a standard diet. Interestingly, CPS offspring and LD fed with HFD showed 20 proteins in common (2 upregulated 18 downregulated). Based on these common proteins, the IPA analysis found that 2 functional pathways were significantly altered; the network 1 (AKT/ERK) and the network 2 (TNF/IL4).

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): White Adipose Tissue

SUBMITTER: Thilo Kaehne  

LAB HEAD: Prof. Dr. Thilo Kaehne

PROVIDER: PXD026315 | Pride | 2021-08-11

REPOSITORIES: Pride

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Richter_perirenal_adipose_CPS125_hfd_a.mgf Mgf
Richter_perirenal_adipose_CPS125_hfd_a.raw Raw
Richter_perirenal_adipose_CPS125_hfd_b.mgf Mgf
Richter_perirenal_adipose_CPS125_hfd_b.raw Raw
Richter_perirenal_adipose_CPS125_hfd_c.mgf Mgf
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Publications

Maternal Chronodisruption Throughout Pregnancy Impairs Glucose Homeostasis and Adipose Tissue Physiology in the Male Rat Offspring.

Halabi Diego D   Richter Hans G HG   Mendez Natalia N   Kähne Thilo T   Spichiger Carlos C   Salazar Esteban E   Torres Fabiola F   Vergara Karina K   Seron-Ferre Maria M   Torres-Farfan Claudia C  

Frontiers in endocrinology 20210816

Compelling evidence in rats support the idea that gestational chronodisruption induces major changes in maternal circadian rhythms and fetal development and that these changes impact adult life at many physiological levels. Using a model of chronic photoperiod shifting throughout gestation (CPS), in which pregnant female rats (Sprague-Dawley strain; <i>n</i> = 16 per group) were exposed to lighting schedule manipulation every 3-4 days reversing the photoperiod completely or light/dark photoperio  ...[more]

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