An economic model of multi-level marketing.
Ontology highlight
ABSTRACT:
SUBMITTER: Reingewertz Y
PROVIDER: S-EPMC8291665 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Project description:The technological development in the new economic era has brought challenges to enterprises. Enterprises need to use massive and effective consumption information to provide customers with high-quality customized services. Big data technology has strong mining ability. The relevant theories of computer data mining technology are summarized to optimize the marketing strategy of enterprises. The application of data mining in precision marketing services is analyzed. Extreme Gradient Boosting (XGBoost) has shown strong advantages in machine learning algorithms. In order to help enterprises to analyze customer data quickly and accurately, the characteristics of XGBoost feedback are used to reverse the main factors that can affect customer activation cards, and effective analysis is carried out for these factors. The data obtained from the analysis points out the direction of effective marketing for potential customers to be activated. Finally, the performance of XGBoost is compared with the other three methods. The characteristics that affect the top 7 prediction results are tested for differences. The results show that: (1) the accuracy and recall rate of the proposed model are higher than other algorithms, and the performance is the best. (2) The significance p values of the features included in the test are all less than 0.001. The data shows that there is a very significant difference between the proposed features and the results of activation or not. The contributions of this paper are mainly reflected in two aspects. 1. Four precision marketing strategies based on big data mining are designed to provide scientific support for enterprise decision-making. 2. The improvement of the connection rate and stickiness between enterprises and customers has played a huge driving role in overall customer marketing.
| S-EPMC10241412 | biostudies-literature
Project description:BackgroundThe pathophysiologic processes underlying the regulation of glucose homeostasis are considerably complex at both cellular and systemic level. A comprehensive and structured specification for the several layers of abstraction of glucose metabolism is often elusive, an issue currently solvable with the hierarchical description provided by multi-level models. In this study we propose a multi-level closed-loop model of whole-body glucose homeostasis, coupled with the molecular specifications of the insulin signaling cascade in adipocytes, under the experimental conditions of normal glucose regulation and type 2 diabetes.Methodology/principal findingsThe ordinary differential equations of the model, describing the dynamics of glucose and key regulatory hormones and their reciprocal interactions among gut, liver, muscle and adipose tissue, were designed for being embedded in a modular, hierarchical structure. The closed-loop model structure allowed self-sustained simulations to represent an ideal in silico subject that adjusts its own metabolism to the fasting and feeding states, depending on the hormonal context and invariant to circadian fluctuations. The cellular level of the model provided a seamless dynamic description of the molecular mechanisms downstream the insulin receptor in the adipocytes by accounting for variations in the surrounding metabolic context.Conclusions/significanceThe combination of a multi-level and closed-loop modeling approach provided a fair dynamic description of the core determinants of glucose homeostasis at both cellular and systemic scales. This model architecture is intrinsically open to incorporate supplementary layers of specifications describing further individual components influencing glucose metabolism.
| S-EPMC5805234 | biostudies-literature
Project description:Metabolism is directly and indirectly fine-tuned by a complex web of interacting regulatory mechanisms that fall into two major classes. On the one hand, the expression level of the catalyzing enzyme sets the maximal theoretical flux level (i.e., the net rate of the reaction) for each enzyme-controlled reaction. On the other hand, metabolic regulation controls the metabolic flux through the interactions of metabolites (substrates, cofactors, allosteric modulators) with the responsible enzyme. High-throughput data, such as metabolomics and transcriptomics data, if analyzed separately, do not accurately characterize the hierarchical regulation of metabolism outlined above. They must be integrated to disassemble the interdependence between different regulatory layers controlling metabolism. To this aim, we propose INTEGRATE, a computational pipeline that integrates metabolomics and transcriptomics data, using constraint-based stoichiometric metabolic models as a scaffold. We compute differential reaction expression from transcriptomics data and use constraint-based modeling to predict if the differential expression of metabolic enzymes directly originates differences in metabolic fluxes. In parallel, we use metabolomics to predict how differences in substrate availability translate into differences in metabolic fluxes. We discriminate fluxes regulated at the metabolic and/or gene expression level by intersecting these two output datasets. We demonstrate the pipeline using a set of immortalized normal and cancer breast cell lines. In a clinical setting, knowing the regulatory level at which a given metabolic reaction is controlled will be valuable to inform targeted, truly personalized therapies in cancer patients.
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Project description:This article describes the data, data flows, and spreadsheet implementations for linking multi-level contribution margin accounting as a subsystem in cost accounting with several versions of a multi-level fixed-charge problem (MLFCP), the latter based on the optimization approach in operations research. This linkage can reveal previously hidden optimization potentials within the framework of multi-level contribution margin accounting, thus providing better information for decision making in companies and other organizations. For the data, plausible fictitious values have been assumed taking into consideration the calculation principles in cost accounting where applicable. They include resource-related data, market-related data, and data from cost accounting needed to analyze the profitability of a company´s products and organizational entities in the presence of hierarchically structured fixed costs. The data are processed and analyzed by means of mathematical optimization techniques and sensitivity analysis. The linkage between multi-level contribution margin accounting and MLFCP is implemented in three spreadsheet files, including versions for deterministic optimization, stochastic optimization, and robust optimization. This paper provides specifications for compatible solver add-ins and for executing sensitivity analysis. The data and spreadsheet implementations described in this article were used in a research article entitled "Making better decisions by applying mathematical optimization to cost accounting: An advanced approach to multi-level contribution margin accounting" [1]. The data sets and the spreadsheet implementations may be reused a) by researchers in management and cost accounting as well as in operations research and quantitative methods for verification and for further development of the linkage concept and of the underlying optimization models; b) by practitioners for gaining insight into the data requirements, methods, and benefits of the proposed linkage, thus supporting continuing education; and c) by instructors in academia who may find the data and spreadsheets valuable for classroom use in advanced courses. The complete spreadsheet implementations in the form of three ready-to-use Excel files (deterministic, stochastic, and robust version) are available for download at Mendeley Data. They may serve as customizable templates for various use cases in research, practice, and education.
| S-EPMC8010628 | biostudies-literature
Project description:Although resources are scarce and outputs incorporate the potential to save human lives, efficiency measurement endeavors with data envelopment analysis (DEA) methods are not yet commonplace in the research and practice of non-government organizations (NGO) and states involved in humanitarian logistics. We present a boot-strapped DEA window analysis and Malmquist index application as a methodological state of the art for a multi-input and multi-output efficiency analysis and discuss specific adaptions to typical core challenges in humanitarian logistics. A characteristic feature of humanitarian operations is the fact that a multitude of organizations are involved on at least two levels, national and supra-national, as well as in two sectors, private NGO and government agencies. This is modeled and implemented in an international empirical analysis: First, a comprehensive dataset from the 34 least developed countries in Africa from 2002 to 2015 is applied for the first time in such a DEA Malmquist index efficiency analysis setting regarding the national state actor level. Second, an analysis of different sections in a Rohingya refugee camp in Bangladesh is analyzed based on a bootstrapped DEA with window analysis application for 2017, 2018, and 2019 quarter data regarding the private NGO level of operations in humanitarian logistics.
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Project description:After the public health event of COVID-19, more academics are looking into how to predict combined economic hazards associated with public health incidents. There are currently just a few approaches for detecting aberrant behaviour in aggregated financial risk, and most only work after the economic risk has already been inappropriately aggregated. As a result, we provide a multi-scale convolutional neural network-based model for clustering financial risk anomaly detection (MCNN). First, we use MCNN to train a model for counting economic risks that are used to evaluate aberrant risk aggregating data. Second, we can use the test results to extract the financial risk statistics and economic risk precursor coordinate points. Then, we calculate the economic risk distribution entropy, distance, potential energy and density. To train the three elements of the development state and create the prediction model, we finally use the particle swarm optimization-based extreme learning machine (PSO-ELM). The results of the experiments demonstrate that, in comparison to existing algorithms, our model can efficiently realize early warning and detect abnormal behaviours of aggregated economic risks with high timeliness. Additionally, our method achieves a forecast accuracy of 97.68% and can give additional time to take emergency action.
| S-EPMC10280538 | biostudies-literature
Project description:There are many modeling works that aim to explain people's behaviors that violate classical economic theories. However, these models often do not take into full account the multi-stage nature of real-life problems and people's tendency in solving complicated problems sequentially. In this work, we propose a descriptive decision-making model for multi-stage problems with perceived post-decision information. In the model, decisions are chosen based on an entity which we call the 'anticipated surprise'. The reference point is determined by the expected value of the possible outcomes, which we assume to be dynamically changing during the mental simulation of a sequence of events. We illustrate how our formalism can help us understand prominent economic paradoxes and gambling behaviors that involve multi-stage or sequential planning. We also discuss how neuroscience findings, like prediction error signals and introspective neuronal replay, as well as psychological theories like affective forecasting, are related to the features in our model. This provides hints for future experiments to investigate the role of these entities in decision-making.
| S-EPMC10770108 | biostudies-literature
Project description:Recent work on the use of mRNA lipoplexes for gene delivery demonstrates the need for a mathematical model that simulates and predicts kinetics and transfection efficiency. The small copy numbers involved make it necessary to use stochastic models and include statistical analysis of the variation observed in the experimental data. The modeling requirements are further complicated by the multi-level nature of the problem, where mRNA molecules are contained in lipoplexes, which are in turn contained in endosomes, where each of these entities displays a behavior of its own. We have created a mathematical model that reproduces both the time courses and the statistical variance observed in recent experiments using single-cell tracking of GFP expression after transfection. By applying a few key simplifications and assumptions, we have limited the number of free parameters to five, which we optimize to match five experimental determinants by means of a simulated annealing algorithm. The models demonstrate the need for modeling of nested species in order to reproduce the shape of the dose-response and expression-level curves.
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Project description:BACKGROUND: Cancer stem cell theory suggests that cancers are derived by a population of cells named Cancer Stem Cells (CSCs) that are involved in the growth and in the progression of tumors, and lead to a hierarchical structure characterized by differentiated cell population. This cell heterogeneity affects the choice of cancer therapies, since many current cancer treatments have limited or no impact at all on CSC population, while they reveal a positive effect on the differentiated cell populations. RESULTS: In this paper we investigated the effect of vaccination on a cancer hierarchical structure through a multi-level model representing both population and molecular aspects. The population level is modeled by a system of Ordinary Differential Equations (ODEs) describing the cancer population's dynamics. The molecular level is modeled using the Petri Net (PN) formalism to detail part of the proliferation pathway. Moreover, we propose a new methodology which exploits the temporal behavior derived from the molecular level to parameterize the ODE system modeling populations. Using this multi-level model we studied the ErbB2-driven vaccination effect in breast cancer. CONCLUSIONS: We propose a multi-level model that describes the inter-dependencies between population and genetic levels, and that can be efficiently used to estimate the efficacy of drug and vaccine therapies in cancer models, given the availability of molecular data on the cancer driving force.
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Project description:Current standard methods for kinetic and genomic modeling cannot provide deep insight into metabolic regulation. Here, we developed and evaluated a multi-scale kinetic modeling approach applicable to any prokaryote. Specifically, we highlight the primary metabolism of the cyanobacterium Synechococcus elongatus PCC 7942. The model bridges metabolic data sets from cells grown at different CO2 conditions by integrating transcriptomic data and isozymes. Identification of the regulatory roles of isozymes allowed the calculation and explanation of the absolute metabolic concentration of 3-phosphoglycerate. To demonstrate that this method can characterize any isozyme, we determined the function of two glycolytic glyceraldehyde-3-phosphate dehydrogenases: one co-regulates high concentrations of the 3-phosphoglycerate, the other shifts the bifurcation point in hexose regulation, and both improve biomass production. Moreover, the regulatory roles of multiple phosphoglycolate phosphatases were defined for varying (non-steady) CO2 conditions, suggesting their protective role against toxic photorespiratory intermediates.
| S-EPMC4138046 | biostudies-literature