Ontology highlight
ABSTRACT:
SUBMITTER: Jablonsky J
PROVIDER: S-EPMC4138046 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Jablonsky Jiri J Schwarz Doreen D Hagemann Martin M
PloS one 20140815 8
Current standard methods for kinetic and genomic modeling cannot provide deep insight into metabolic regulation. Here, we developed and evaluated a multi-scale kinetic modeling approach applicable to any prokaryote. Specifically, we highlight the primary metabolism of the cyanobacterium Synechococcus elongatus PCC 7942. The model bridges metabolic data sets from cells grown at different CO2 conditions by integrating transcriptomic data and isozymes. Identification of the regulatory roles of isoz ...[more]