Killing conspecific adults in mammals.
Ontology highlight
ABSTRACT:
SUBMITTER: Gomez JM
PROVIDER: S-EPMC8292775 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Project description:Plants release volatiles in response to caterpillar feeding that attract natural enemies of the herbivores, a tri-trophic interaction which has been considered an indirect plant defence against herbivores. The caterpillar-induced plant volatiles have been reported to repel or attract conspecific adult herbivores. To date however, no volatile signals that either repel or attract conspecific adults under field conditions have been chemically identified. Apple seedlings uniquely released seven compounds including acetic acid, acetic anhydride, benzyl alcohol, benzyl nitrile, indole, 2-phenylethanol, and (E)-nerolidol only when infested by larvae of the light brown apple moth, Epiphyas postvittana. In field tests in New Zealand, a blend of two of these, benzyl nitrile and acetic acid, attracted a large number of conspecific male and female adult moths. In North America, male and female adults of the tortricid, oblique-banded leafroller, Choristoneura rosaceana, were most attracted to a blend of 2-phenylethanol and acetic acid. Both sexes of the eye-spotted bud moth, Spilonota ocellana, were highly attracted to a blend of benzyl nitrile and acetic acid. This study provides the first identification of caterpillar-induced plant volatiles that attract conspecific adult herbivores under natural conditions, challenging the expectation of herbivore avoidance of these induced volatiles.
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Project description:Canine conspecific coprophagy, the tendency or predisposition of some dogs to eat their own faeces or those of other dogs, seems paradoxical because dogs typically show an aversion to conspecific faeces. In an attempt to resolve this paradox, we set out to determine the factors associated with the occurrence of this behaviour and to evaluate the efficacy of 11 products marketed for treating coprophagy as well as behaviour modification procedures. Because a large sample of dogs was needed to address these issues, two web-based surveys were utilized. One, intended to compare coprophagic dogs and non-coprophagic dogs, yielded 1552 returns. The other, yielding 1475 usable returns, specifically recruited owners of coprophagic dogs to gather information about the characteristics of coprophagy and treatment success. The findings revealed that 16% of dogs sampled engaged in frequent conspecific coprophagy, defined as having been seen eating stools at least six times. No evidence was found relating the coprophagy to diet or the dog's age. Coprophagic dogs were as easily house trained as non-coprophagic dogs, suggesting a normal aversion to faeces. Coprophagic dogs were more likely to be reported as greedy eaters than non-coprophagic dogs. The reported success rate of the commercial products and behaviour modification approaches was close to zero, indicating that the behaviour is not readily changed. The coprophagy was overwhelmingly directed at fresh stools, defined as being no more than 2 days old. A hypothesis is offered that coprophagy reflects a tendency inherited from the ancestral wolf to keep the den area free of faecal-borne intestinal parasites that might be deposited in the den resting area and would typically have parasite ova that are not initially infective, but could develop infective larvae after 2 days. An evolved parasite defence strategy to consume fresh faeces in the rest area would be adaptive.
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Project description:Active defense against a conspecific aggressor is essential for survival. Previous studies revealed strong c-Fos expression in the ventrolateral part of the ventromedial hypothalamus (VMHvl) in defeated animals. Here, we examined the functional relevance and in vivo responses of the VMHvl during conspecific defense. We found that VMHvl cells expressing estrogen receptor α (Esr1) are acutely excited during active conspecific defense. Optogenetic inhibition of the cells compromised an animal's ability to actively defend against an aggressor, whereas activating the cells elicited defense-like behaviors. Furthermore, the VMHvl is known for its role in aggression. In vivo recording and c-Fos mapping revealed differential organization of the defense and aggression-responsive cells in the VMHvl. Specifically, defense-activated cells are concentrated in the anterior part of the VMHvl, which preferentially targets the periaqueductal gray (PAG). Thus, our study identified an essential neural substrate for active conspecific defense and expanded the function of the VMHvl.
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Project description:Transcriptional profiling of courtship song stimulated females in Drosophila melanogaster comparing females exposed to conspecific song to those exposed to either white-noise (control) or heterospecific song (D. simulans)
2011-11-22 | GSE31190 | GEO
Project description:Eculizumab, a humanized anti-complement C5 monoclonal antibody (mAb) for treatment of paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome, blocks the terminal complement pathway required for serum bactericidal activity (SBA). Because treated patients are at >1000-fold increased risk of meningococcal disease, vaccination is recommended; whether vaccination can protect by opsonophagocytic activity in the absence of SBA is not known. Meningococci were added to anticoagulated blood from 12 healthy adults vaccinated with meningococcal serogroup B and serogroup A, C, W, Y vaccines. Bacterial survival was measured after 3-hour incubation in the presence of eculizumab or control complement factor D inhibitor ACH-4471, which blocks the complement alternative pathway (AP) and is in phase 2 development for treatment of PNH. In the absence of inhibitors, colony formation units (CFUs) per milliliter in blood from all 12 immunized subjects decreased from ∼4000 at time 0 to sterile cultures at 3 hours. In the presence of eculizumab, there was a >22-fold increase in geometric mean CFUs per milliliter (90 596 and 114 683 CFU/mL for serogroup B and C strains, respectively; P < .0001 compared with time 0). In the presence of ACH-4471, there was a >12-fold decrease (23 and 331 CFU/mL, respectively; P < .0001). The lack of meningococci killing by blood containing eculizumab resulted from inhibition of release of C5a, a C5 split product needed for upregulation of phagocytosis. The results provide an explanation for the large number of cases of meningococcal disease in immunized patients being treated with eculizumab and suggest that vaccination may provide better protection against meningococcal disease in patients treated with an AP-specific inhibitor.
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Project description:In the late 1930s, Karl von Frisch reported that semiochemicals released upon injury, act as alarm substances (Schreckstoff) in fish. In Ostariophysi species, club cells in the epidermis are believed to contain cues related to alarm substance; however, the function of club cells, primarily as reservoirs of alarm substance has been debated. Here, I describe an alarm response in the Japanese rice fish Oryzias latipes (medaka), a member of the order Beloniformes. The response to alarm substance (Schreckreaction) in medaka is characterized by bouts of immobility and an increase in cortisol levels within minutes of exposure to conspecific skin extract. Histological analysis, however, suggests that club cells are either rare or absent in the medaka epidermis. In addition to describing an uncharacterized behavior in a vertebrate popular for genetic and developmental studies, these results support the hypothesis that the primary function of epidermal club cells may be unrelated to a role as alarm substance cells. The existence of similar behavioral responses in two evolutionarily distant but well established laboratory models, the zebrafish and the medaka, offers the possibility of comparative analyses of neural circuits encoding innate fear.
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Project description:How do organisms balance different types of recognition errors when cues associated with desirable and undesirable individuals or resources overlap? This is a fundamental question of signal detection theory (SDT). As applied in sociobiology, SDT is not limited to a single context or animal taxon, therefore its application can span what may be considered dissimilar systems. One of the applications of SDT is the suite of acceptance threshold models proposed by Reeve (1989), which analysed how individuals should balance acceptance and rejection errors in social discrimination decisions across a variety of recognition contexts, distinguished by how these costs and benefits relatively combine. We conducted a literature review to evaluate whether these models' specific predictions have been upheld. By examining over 350 research papers, we quantify how Reeve's models (Reeve 1989 Am. Nat. 133, 407-435 (doi:10.1086/284926)) have influenced the field of ecological and behavioural recognition systems research. We found overall empirical support for the predictions of the specific models proposed by Reeve, and argue for further expansion of their applications into more diverse taxonomic and additional recognition contexts. This article is part of the theme issue 'Signal detection theory in recognition systems: from evolving models to experimental tests'.
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Project description:Conspecific adults have strong negative effect on the survival of nearby early-stage seedlings and thus can promote species coexistence by providing space for the regeneration of heterospecifics. The leaf litter fall from the conspecific adults, and it could mediate this conspecific negative adult effect. However, field evidence for such effect of conspecific leaf litter remains absent. In this study, we used generalized linear mixed models to assess the effects of conspecific leaf litter on the early-stage seedling survival of four dominant species (Machilus leptophylla, Litsea elongate, Acer pubinerve and Distylium myricoides) in early-stage seedlings in a subtropical evergreen broad-leaved forest in eastern China. Our results consistently showed that the conspecific leaf litter of three species negatively affected the seedling survival. Meanwhile, the traditional conspecific adult neighborhood indices failed to detect this negative conspecific adult effect. Our study revealed that the accumulation of conspecific leaf litter around adults can largely reduce the survival rate of nearby seedlings. Ignoring it could result in underestimation of the importance of negative density dependence and negative species interactions in the natural forest communities.
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Project description:Recent evidence has shown that humans are remarkably sensitive to artificial cues of conspecific observation when making decisions with potential social consequences. Whether similar effects are found in other great apes has not yet been investigated. We carried out two experiments in which individual chimpanzees, Pan troglodytes, took items of food from an array in the presence of either an image of a large conspecific face or a scrambled control image. In experiment 1 we compared three versions of the face image varying in size and the amount of the face displayed. In experiment 2 we compared a fourth variant of the image with more prominent coloured eyes displayed closer to the focal chimpanzee. The chimpanzees did not look at the face images significantly more than at the control images in either experiment. Although there were trends for some individuals in each experiment to be slower to take high-value food items in the face conditions, these were not consistent or robust. We suggest that the extreme human sensitivity to cues of potential conspecific observation may not be shared with chimpanzees.
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Project description:A central question related to virtually all social decisions is how animals integrate sex-specific cues from conspecifics. Using microendoscopic calcium imaging in mice, we find that sex information is represented in the dorsal medial prefrontal cortex (dmPFC) across excitatory and inhibitory neurons. These cells form a distributed code that differentiates the sex of conspecifics and is strengthened with social experience. While males and females both represent sex in the dmPFC, male mice show stronger encoding of female cues, and the relative strength of these sex representations predicts sex preference behavior. Using activity-dependent optogenetic manipulations of natively active ensembles, we further show that these specific representations modulate preference behavior toward males and females. Together, these results define a functional role for native representations of sex in shaping social behavior and reveal a neural mechanism underlying male- versus female-directed sociality.
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