Hypoxia and hypocapnia storage of γ-irradiated red cell concentrates.

ABSTRACT:

Background

γ-irradiation is used to treat red blood cell (RBC) concentrates (RCCs) transfused to immunosuppressed patients. This treatment damages RBCs and increases storage lesions. Several studies have shown the beneficial effect of reducing O₂ content during RBC storage. The present research work investigated the effect of γ-irradiation on RCCs stored under normal and hypoxia/hypocapnia conditions.

Materials and methods

O₂ concentration (measured as oxyhaemoglobin fraction, sO₂) and ABO-matched RCCs from whole blood donations, leukoreduced and prepared in phosphate, adenine, glucose, guanosine, saline and mannitol (PAGGSM) were pooled and split in two identical RCCs within 24 h post donation. One bag (Hx) was submitted to O₂ and

SUBMITTER: Bardyn M 

PROVIDER: S-EPMC8297680 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature