Ontology highlight
ABSTRACT:
SUBMITTER: Kerckhoffs KGP
PROVIDER: S-EPMC8298358 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Kerckhoffs K G P KGP Aallali T T Ambarus C A CA Sigurdsson V V Jansen A M L AML Blokx W A M WAM
Virchows Archiv : an international journal of pathology 20201011 1
The molecular background of a significant proportion of spitzoid neoplasms is still unknown. Recently, activating mutations in MAP2K1 have been described in a few spitzoid lesions, but not in benign Spitz nevi. We report four cases of melanocytic tumors with spitzoid features in which a MAP2K1 mutation was detected. The lesions did not show a single distinct phenotype and ranged from benign to malignant. Two cases resembled desmoplastic Spitz nevi. Based on the combination of morphological, immu ...[more]