Expanding spectrum of "spitzoid" lesions: a small series of 4 cases with MAP2K1 mutations.

ABSTRACT: The molecular background of a significant proportion of spitzoid neoplasms is still unknown. Recently, activating mutations in MAP2K1 have been described in a few spitzoid lesions, but not in benign Spitz nevi. We report four cases of melanocytic tumors with spitzoid features in which a MAP2K1 mutation was detected. The lesions did not show a single distinct phenotype and ranged from benign to malignant. Two cases resembled desmoplastic Spitz nevi. Based on the combination of morphological, immunohistochemical, and molecular findings, one case was classified as benign, one as probably benign, possibly intermediate low-grade (MELTUMP-melanocytic tumor of unknown malignant potential), one case was classified as intermediate (MELTUMP), and one case was considered a superficial spreading melan

SUBMITTER: Kerckhoffs KGP 

PROVIDER: S-EPMC8298358 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature