Skin under Strain: From Epithelial Model Tissues to Adult Epithelia.

ABSTRACT: Formation of a barrier capable of protecting tissue from external damage, chemical factors, and pathogens is one of the main functions of the epidermis. Furthermore, upon development and during aging, mechanoprotective epidermal functions change dramatically. However, comparative studies between embryonic and adult skin in comparison to skin equivalents are still scarce which is especially due to the lack of appropriate measurement systems with sufficient accuracy and long-term tissue compatibility. Our studies fill this gap by developing a combined bioreactor and tensile testing machine for biomechanical analysis of living epithelia. Based on this tissue stretcher, our data clearly show that viscoelastic and plastic deformation behavior of embryonic and adult skin differ significantly. Ti

SUBMITTER: Pullen R 

PROVIDER: S-EPMC8304960 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature