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New Diterpenoids and Isocoumarin Derivatives from the Mangrove-Derived Fungus Hypoxylon sp.

ABSTRACT: Two new diterpenoids, hypoxyterpoids A (1) and B (2), and four new isocoumarin derivatives, hypoxymarins A-D (4-7), together, with seven known metabolites (3 and 8-13) were obtained from the crude extract of the mangrove-derived fungus Hypoxylon sp. The structures of the new compounds were elucidated on the basis of 1- and 2-dimensional (1D/2D) nuclear magnetic resonance (NMR) spectroscopic and mass spectrometric analysis. The absolute configurations of compounds 1, 2, 4, 5, and 7 were determined by comparison of experimental and calculated electronic circular dichroism (ECD) spectra, and the absolute configurations of C-4' in 6 and C-9 in 7 were determined by [Rh2(OCOCF3)4]-induced ECD spectra. Compound 1 showed moderate α-glucosidase inhibitory activities with IC50 values of 741.5 ± 2.83 μM. Compounds 6 and 11 exhibited DPPH scavenging activities with IC50 values of 15.36 ± 0.24 and 3.69 ± 0.07 μM, respectively.

SUBMITTER: Hou B 

PROVIDER: S-EPMC8305793 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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New Diterpenoids and Isocoumarin Derivatives from the Mangrove-Derived Fungus <i>Hypoxylon</i> sp.

Hou Bolin B   Liu Sushi S   Huo Ruiyun R   Li Yueqian Y   Ren Jinwei J   Wang Wenzhao W   Wei Tao T   Jiang Xuejun X   Yin Wenbing W   Liu Hongwei H   Liu Ling L   Li Erwei E  

Marine drugs 20210624 7

Two new diterpenoids, hypoxyterpoids A (<b>1</b>) and B (<b>2</b>), and four new isocoumarin derivatives, hypoxymarins A-D (<b>4</b>-<b>7</b>), together, with seven known metabolites (<b>3</b> and <b>8</b>-<b>13</b>) were obtained from the crude extract of the mangrove-derived fungus <i>Hypoxylon</i> sp. The structures of the new compounds were elucidated on the basis of 1- and 2-dimensional (1D/2D) nuclear magnetic resonance (NMR) spectroscopic and mass spectrometric analysis. The absolute conf  ...[more]

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