Microbiome signatures of progression toward celiac disease onset in at-risk children in a longitudinal prospective cohort study.

ABSTRACT: Other than exposure to gluten and genetic compatibility, the gut microbiome has been suggested to be involved in celiac disease (CD) pathogenesis by mediating interactions between gluten/environmental factors and the host immune system. However, to establish disease progression markers, it is essential to assess alterations in the gut microbiota before disease onset. Here, a prospective metagenomic analysis of the gut microbiota of infants at risk of CD was done to track shifts in the microbiota before CD development. We performed cross-sectional and longitudinal analyses of gut microbiota, functional pathways, and metabolites, starting from 18 mo before CD onset, in 10 infants who developed CD and 10 matched nonaffected infants. Cross-sectional analysis at CD onset identified altered abun

SUBMITTER: Leonard MM 

PROVIDER: S-EPMC8307711 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature