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Seroprevalence of Anti-SARS-CoV-2 Antibodies in Blood Donors from Nuevo Leon State, Mexico, during 2020: A Retrospective Cross-Sectional Evaluation.


ABSTRACT: The progression and distribution of the SARS-CoV-2 pandemic are continuously changing over time and can be traced by blood donors' serological survey. Here, we investigated the seroprevalence of anti-SARS-CoV-2 antibodies in blood donors in Nuevo Leon, Mexico during 2020 as a strategy for the rapid evaluation of the spread of SARS-CoV-2 and asymptomatic case detection. We collected residual plasma samples from blood donors who attended two regional donation centers from January to December of 2020 to identify changes in anti-SARS-CoV-2 IgG prevalence. Plasma samples were analyzed on the Abbott Architect instrument using the commercial Abbott SARS-CoV-2 IgG chemiluminescent assay. We found a total of 99 reactive samples from 2068 analyzed plasma samples, resulting in a raw prevalence of 4.87%. Donors aged 18-49 years were more likely to be seropositive compared to those aged >50 years (p < 0.001). Weekly seroprevalence increased from 1.8% during the early pandemic stage to 27.59% by the end of the year. Prevalence was 1.46-fold higher in females compared to males. Case geographical mapping showed that Monterrey city recorded the majority of SARS-CoV-2 cases. These results show that there is a growing trend of seroprevalence over time associated with asymptomatic infection that is unnoticed under the current epidemiological surveillance protocols.

SUBMITTER: Martinez-Acuna N 

PROVIDER: S-EPMC8310175 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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Seroprevalence of Anti-SARS-CoV-2 Antibodies in Blood Donors from Nuevo Leon State, Mexico, during 2020: A Retrospective Cross-Sectional Evaluation.

Martinez-Acuña Natalia N   Avalos-Nolazco Diana Minerva DM   Rodriguez-Rodriguez Diana Raquel DR   Martinez-Liu Cynthia Gabriela CG   Galan-Huerta Kame Alberto KA   Padilla-Rivas Gerardo Raymundo GR   Ramos-Jimenez Javier J   Ayala-de-la-Cruz Sergio S   Cienfuegos-Pecina Eduardo E   Diaz-Chuc Erik Alejandro EA   Cazares-Tamez Rogelio R   Flores-Arechiga Amador A   Perez-Chavez Fernando F   Arellanos-Soto Daniel D   Lozano-Sepulveda Sonia Amelia SA   Garza-Gonzalez Elvira E   Treviño-Garza Consuelo C   Montes-de-Oca-Luna Roberto R   Lee-Gonzalez Aurora Beatriz AB   de-la-O-Cavazos Manuel Enrique ME   Rivas-Estilla Ana Maria AM  

Viruses 20210624 7


The progression and distribution of the SARS-CoV-2 pandemic are continuously changing over time and can be traced by blood donors' serological survey. Here, we investigated the seroprevalence of anti-SARS-CoV-2 antibodies in blood donors in Nuevo Leon, Mexico during 2020 as a strategy for the rapid evaluation of the spread of SARS-CoV-2 and asymptomatic case detection. We collected residual plasma samples from blood donors who attended two regional donation centers from January to December of 20  ...[more]

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