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Study of the Langat virus RNA-dependent RNA polymerase through homology modeling.

ABSTRACT: Langat virus is a member of the Flaviviridae family and a close relative of a group of important tick-borne viruses that cause human encephalitis. RNA-dependent RNA polymerase is a significant component of the replication mechanism of the Flaviviridae viral family. In the present work, a three-dimensional model of the Langat virus RNA-dependent RNA polymerase was designed through homology modeling. The experimentally determined structure of the RNA-dependent RNA polymerase of Dengue virus type II, another member of the same viral family, was employed as template for the homology modeling process. The resulting model underwent a series of optimisations and its quality was verified using the Verify3D algorithm. Important functional characteristics of the family of viral RNA-dependent RNA polymerases were identified in the generated model, thus affirming the potential for its use in the possible design of anti-viral agents for Langat virus.

SUBMITTER: Diakou KI

PROVIDER: S-EPMC8312719 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Study of the Langat virus RNA-dependent RNA polymerase through homology modeling.

Diakou Kalliopi Io KI Mitsis Thanasis T Pierouli Katerina K Papakonstantinou Eleni E Megalooikonomou Vasileios V Efthimiadou Aspasia A Vlachakis Dimitrios D

EMBnet.journal 20210629 1

Langat virus is a member of the <i>Flaviviridae</i> family and a close relative of a group of important tick-borne viruses that cause human encephalitis. RNA-dependent RNA polymerase is a significant component of the replication mechanism of the <i>Flaviviridae</i> viral family. In the present work, a three-dimensional model of the Langat virus RNA-dependent RNA polymerase was designed through homology modeling. The experimentally determined structure of the RNA-dependent RNA polymerase of Dengu ...[more]

PMID: 34316455

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Dataset Information

Study of the Langat virus RNA-dependent RNA polymerase through homology modeling.

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Study of the Langat virus RNA-dependent RNA polymerase through homology modeling.

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