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Intranasal vaccines for SARS-CoV-2: From challenges to potential in COVID-19 management.

ABSTRACT: Unlike conventional Coronavirus 2019 (COVID-19) vaccines, intranasal vaccines display a superior advantage because the nasal mucosa is often the initial site of infection. Preclinical and clinical studies concerning intranasal immunization elicit high neutralizing antibody generation and mucosal IgA and T cell responses that avoid severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in both; the upper and lower respiratory tract. A nasal formulation is non-invasive with high appeal to patients. Intranasal vaccines enable self-administration and can be designed to survive at ambient temperatures, thereby simplifying logistical aspects of transport and storage. In this review, we provide an overview of nasal vaccines with a focus on formulation development as well as ongoing preclinical and clinical studies for SARS-CoV-2 intranasal vaccine products.

SUBMITTER: Chavda VP

PROVIDER: S-EPMC8319039 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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Intranasal vaccines for SARS-CoV-2: From challenges to potential in COVID-19 management.

Chavda Vivek P VP Vora Lalitkumar K LK Pandya Anjali K AK Patravale Vandana B VB

Drug discovery today 20210729 11

Unlike conventional Coronavirus 2019 (COVID-19) vaccines, intranasal vaccines display a superior advantage because the nasal mucosa is often the initial site of infection. Preclinical and clinical studies concerning intranasal immunization elicit high neutralizing antibody generation and mucosal IgA and T cell responses that avoid severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in both; the upper and lower respiratory tract. A nasal formulation is non-invasive with high ap ...[more]

PMID: 34332100

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