Ontology highlight
ABSTRACT:
SUBMITTER: Baer SL
PROVIDER: S-EPMC8319090 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Baer Stephanie L SL Colombo Rhonda E RE Johnson Maribeth H MH Wakade Sushama S Pacholczyk Gabriela G Newman-Whitlow Cheryl C Thompson Stuart A SA Saag Michael S MS Martin Jeffrey N JN Floris-Moore Michelle M Huang Lei L Mellor Andrew L AL
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20210419 6
Immune activation complicates HIV despite antiretroviral therapy (ART). Indoleamine 2,3 dioxygenase (IDO) catabolizes tryptophan (T) to kynurenine (K), regulating immune activity, and IDO activity increases with age. This study examines the relationship of IDO activity, bacterial translocation, and aging in people living with HIV (PLWH) on ART. Samples and data from PLWH on ART from the Centers for AIDS Research Network of Integrated Clinical Systems and from matched HIV-uninfected patients (con ...[more]