Ontology highlight
ABSTRACT:
SUBMITTER: Hommes JW
PROVIDER: S-EPMC8319287 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Hommes Josefien W JW Kratofil Rachel M RM Wahlen Sigrid S de Haas Carla J C CJC Hildebrand Reeni B RB Hovingh G Kees GK Otto Micheal M van Eck Miranda M Hoekstra Menno M Korporaal Suzanne J A SJA Surewaard Bas G J BGJ
Scientific reports 20210728 1
Staphylococcus aureus virulence has been associated with the production of phenol-soluble modulins (PSMs). These PSMs have distinct virulence functions and are known to activate, attract and lyse neutrophils. These PSM-associated biological functions are inhibited by lipoproteins in vitro. We set out to address whether lipoproteins neutralize staphylococcal PSM-associated virulence in experimental animal models. Serum from both LCAT an ABCA1 knockout mice strains which are characterised by near ...[more]