A Computational Exploration of the Molecular Network Associated to Neuroinflammation in Alzheimer's Disease.

ABSTRACT: Neuroinflammation, as defined by the presence of classically activated microglia, is thought to play a key role in numerous neurodegenerative disorders such as Alzheimer's disease. While modulating neuroinflammation could prove beneficial against neurodegeneration, identifying its most relevant biological processes and pharmacological targets remains highly challenging. In the present study, we combined text-mining, functional enrichment and protein-level functional interaction analyses to 1) identify the proteins significantly associated to neuroinflammation in Alzheimer's disease over the scientific literature, 2) distinguish the key proteins most likely to control the neuroinflammatory processes significantly associated to Alzheimer's disease, 3) identify their regulatory microRNAs amon

SUBMITTER: El Idrissi F 

PROVIDER: S-EPMC8319636 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature