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The Role of TGF-β Signaling Pathways in Cancer and Its Potential as a Therapeutic Target.

ABSTRACT: The transforming growth factor-β (TGF-β) signaling pathway mediates various biological functions, and its dysregulation is closely related to the occurrence of malignant tumors. However, the role of TGF-β signaling in tumorigenesis and development is complex and contradictory. On the one hand, TGF-β signaling can exert antitumor effects by inhibiting proliferation or inducing apoptosis of cancer cells. On the other hand, TGF-β signaling may mediate oncogene effects by promoting metastasis, angiogenesis, and immune escape. This review summarizes the recent findings on molecular mechanisms of TGF-β signaling. Specifically, this review evaluates TGF-β's therapeutic potential as a target by the following perspectives: ligands, receptors, and downstream signaling. We hope this review can trigger new ideas to improve the current clinical strategies to treat tumors related to the TGF-β signaling pathway.

SUBMITTER: Yang Y 

PROVIDER: S-EPMC8321733 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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The Role of TGF-<i>β</i> Signaling Pathways in Cancer and Its Potential as a Therapeutic Target.

Yang Yun Y   Ye Wen-Long WL   Zhang Ruo-Nan RN   He Xiao-Shun XS   Wang Jing-Ru JR   Liu Yu-Xuan YX   Wang Yi Y   Yang Xue-Mei XM   Zhang Yu-Juan YJ   Gan Wen-Juan WJ  

Evidence-based complementary and alternative medicine : eCAM 20210722

The transforming growth factor-<i>β</i> (TGF-<i>β</i>) signaling pathway mediates various biological functions, and its dysregulation is closely related to the occurrence of malignant tumors. However, the role of TGF-<i>β</i> signaling in tumorigenesis and development is complex and contradictory. On the one hand, TGF-<i>β</i> signaling can exert antitumor effects by inhibiting proliferation or inducing apoptosis of cancer cells. On the other hand, TGF-<i>β</i> signaling may mediate oncogene eff  ...[more]

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