Ontology highlight
ABSTRACT:
SUBMITTER: Yu D
PROVIDER: S-EPMC8323476 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Yu Dahang D Wang Zhe Z Cupp-Sutton Kellye A KA Guo Yanting Y Kou Qiang Q Smith Kenneth K Liu Xiaowen X Wu Si S
Journal of the American Society for Mass Spectrometry 20210316 6
Labeling approaches using isobaric chemical tags (e.g., isobaric tagging for relative and absolute quantification, iTRAQ and tandem mass tag, TMT) have been widely applied for the quantification of peptides and proteins in bottom-up MS. However, until recently, successful applications of these approaches to top-down proteomics have been limited because proteins tend to precipitate and "crash" out of solution during TMT labeling of complex samples making the quantification of such samples difficu ...[more]