Ontology highlight
ABSTRACT:
SUBMITTER: Deng L
PROVIDER: S-EPMC8323615 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Deng Lan L Wang Hongxin H Dapper Christie H CH Newton William E WE Shilov Sergey S Wang Shunlin S Cramer Stephen P SP Zhou Zhao-Hui ZH
Communications chemistry 20201028
Protonation of FeMo-cofactor is important for the process of substrate hydrogenation. Its structure has been clarified as Δ-Mo*Fe<sub>7</sub>S<sub>9</sub>C(<i>R</i>-homocit*)(cys)(Hhis) for the efforts of nearly 30 years, while it remains controversial whether FeMo-cofactor is protonated or deprotonated with chelated ≡C-O(H) homocitrate. We have used protonated molybdenum(V) lactates <b>1</b> and its enantiomer as model compounds for <i>R</i>-homocitrate in FeMo-cofactor of nitrogenase. Vibratio ...[more]