Evaluation of Positive End-Expiratory Pressure Strategies in Patients With Coronavirus Disease 2019-Induced Acute Respiratory Distress Syndrome.

ABSTRACT: Background: Different positive end-expiratory pressure (PEEP) strategies are available for subjects with coronavirus disease 2019 (COVID-19)-induced acute respiratory distress syndrome (ARDS) requiring invasive mechanical ventilation. We aimed to evaluate three conventional PEEP strategies on their effects on respiratory mechanics, gas exchanges, and hemodynamics. Methods: This is a prospective, physiologic, multicenter study conducted in China. We recruited 20 intubated subjects with ARDS and confirmed COVID-19. We first set PEEP by the ARDSnet low PEEP-fraction of inspired oxygen (FIO₂) table. After a recruitment maneuver, PEEP was set at 15, 10, and 5 cm H₂O for 10 min, respectively. Among these three PEEP levels, best-compliance PEEP was the one prov

SUBMITTER: Pan C 

PROVIDER: S-EPMC8329249 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature