Unknown

Dataset Information

0

Long Non-coding RNA T-uc.189 Modulates Neural Progenitor Cell Fate by Regulating Srsf3 During Mouse Cerebral Cortex Development.


ABSTRACT: Neurogenesis is a complex process that depends on the delicate regulation of spatial and temporal gene expression. In our previous study, we found that transcribed ultra-conserved regions (T-UCRs), a class of long non-coding RNAs that contain UCRs, are expressed in the developing nervous systems of mice, rhesus monkeys, and humans. In this study, we first detected the full-length sequence of T-uc.189, revealing that it was mainly concentrated in the ventricular zone (VZ) and that its expression decreased as the brain matured. Moreover, we demonstrated that knockdown of T-uc.189 inhibited neurogenesis. In addition, we found that T-uc.189 positively regulated the expression of serine-arginine-rich splicing factor 3 (Srsf3). Taken together, our results are the first to demonstrate that T-uc.189 regulates the expression of Srsf3 to maintain normal neurogenesis during cortical development.

SUBMITTER: Zhang M 

PROVIDER: S-EPMC8329457 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC8202844 | biostudies-literature
| S-EPMC2723068 | biostudies-literature
| S-EPMC5800915 | biostudies-literature
| S-EPMC5556025 | biostudies-literature
| S-EPMC4287277 | biostudies-literature
| S-EPMC2897740 | biostudies-literature
| S-EPMC4221195 | biostudies-literature
| S-EPMC3463886 | biostudies-other
| S-EPMC5482607 | biostudies-literature
| S-EPMC6326801 | biostudies-literature