Prevalence and risk factors for antimicrobial resistance among newborns with gram-negative sepsis.

ABSTRACT:

Introduction

Newborn sepsis accounts for more than a third of neonatal deaths globally and one in five neonatal deaths in Ethiopia. The first-line treatment recommended by WHO is the combination of gentamicin with ampicillin or benzylpenicillin. Gram-negative bacteria (GNB) are increasingly resistant to previously effective antibiotics.

Objectives

Our goal was to estimate the prevalence of antibiotic-resistant gram-negative bacteremia and identify risk factors for antibiotic resistance, among newborns with GNB sepsis.

Methods

At a tertiary hospital in Ethiopia, we enrolled a cohort pregnant women and their newborns, between March and December 2017. Newborns who were followed up until 60 days of life for clinical signs of sepsis. Among the newborns with clinical signs

SUBMITTER: Solomon S 

PROVIDER: S-EPMC8330902 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature