Ontology highlight
ABSTRACT:
SUBMITTER: Diaz Del Moral S
PROVIDER: S-EPMC8339973 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Díaz Del Moral Sandra S Barrena Silvia S Hernández-Torres Francisco F Aránega Amelia A Villaescusa José Manuel JM Gómez Doblas Juan José JJ Franco Diego D Jiménez-Navarro Manuel M Muñoz-Chápuli Ramón R Carmona Rita R
Frontiers in cell and developmental biology 20210722
Expression of Wilms' tumor suppressor transcription factor (WT1) in the embryonic epicardium is essential for cardiac development, but its myocardial expression is little known. We have found that WT1 is expressed at low levels in 20-25% of the embryonic cardiomyocytes. Conditional ablation of WT1 using a cardiac troponin T driver (Tnnt2 <sup><i>Cre</i></sup> ) caused abnormal sinus venosus and atrium development, lack of pectinate muscles, thin ventricular myocardium and, in some cases, interve ...[more]