The inflation response of the human lamina cribrosa and sclera: Analysis of deformation and interaction.

ABSTRACT: This study investigated the inflation response of the lamina cribrosa (LC) and adjacent peripapillary sclera (PPS) in post-mortem human eyes with no history of glaucoma. The posterior sclera of 13 human eyes from 7 donors was subjected to controlled pressurization between 5-45 mmHg. A laser-scanning microscope (LSM) was used to image the second harmonic generation (SHG) response of collagen and the two-photon fluorescent (TPF) response of elastin within the volume of the LC and PPS at each pressure. Image volumes were analyzed using digital volume correlation (DVC) to calculate the three-dimensional (3D) deformation field between pressures. The LC exhibited larger radial strain, E_rr, and maximum principal strain, E_max, (p < 0.0001) and greater posterior displacement (

SUBMITTER: Midgett DE 

PROVIDER: S-EPMC8340454 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature