Withanolides from Physalis angulata L.

ABSTRACT: The compounds (17S,20R,22R,24R,25S)-5β,6β:20,24-diep-oxy-4β,25-dihy-droxy-1-oxowith-2-en-26,22-olide and (20R,22R)-5α,14α,20-Trihy-droxy-1-oxo-6α,7α-ep-oxy-witha-2-enolide were isolated from a chloro-form extract of the aerial parts of Physalis angulata L. (Solanaceae). Two products were isolated from the chromatographic separation extract. Compound I corresponds to physangulide B chloro-form monosolvate, C₂₈H₃₈O₇·CHCl₃, while compound II is 14α-hy-droxy-ixocarpanolide, C₂₈H₄₀O₇. In the two mol-ecular structures, the conformation of the steroid part (rings A, B, C, D) does not differ. In both crystals, mol-ecules are linked by inter-molecular O-H⋯O hydrogen bonds along the c-axis direction and form a two-dimensional network parallel to the ac plane. The absolute configuration was determined from X-ray diffraction data.

SUBMITTER: Okmanov RY 

PROVIDER: S-EPMC8340980 | biostudies-literature |

REPOSITORIES: biostudies-literature