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Cellular internalization mechanism of novel Raman probes designed for plant cells.

ABSTRACT: Diphenylacetylene derivatives containing different polymeric components, poly(l-lysine) (pLys) or tetra(ethylene glycol) (TEG) were designed as novel Raman imaging probes with high Raman sensitivity and low cytotoxicity in living plant cells. The pLys-conjugated probe is internalized via an endocytosis-dependent pathway, whereas TEG-conjugated probe most likely induces direct penetration into the plant cells.

SUBMITTER: Midorikawa K

PROVIDER: S-EPMC8341950 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Cellular internalization mechanism of novel Raman probes designed for plant cells.

Midorikawa Keiko K Tsuchiya Kousuke K Law Simon Sau Yin SSY Miyagi Yu Y Asai Takuya T Iino Takanori T Ozeki Yasuyuki Y Kodama Yutaka Y Numata Keiji K

RSC chemical biology 20200820 4

Diphenylacetylene derivatives containing different polymeric components, poly(l-lysine) (pLys) or tetra(ethylene glycol) (TEG) were designed as novel Raman imaging probes with high Raman sensitivity and low cytotoxicity in living plant cells. The pLys-conjugated probe is internalized <i>via</i> an endocytosis-dependent pathway, whereas TEG-conjugated probe most likely induces direct penetration into the plant cells. ...[more]

PMID: 34458759

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