Tolvaptan in ADPKD Patients With Very Low Kidney Function.

ABSTRACT:

Introduction

Tolvaptan slowed estimated glomerular filtration rate (eGFR) decline in subjects with autosomal dominant polycystic kidney disease (ADPKD) in TEMPO 3:4 and REPRISE trials. Tolvaptan effects in subjects with eGFR 15 to 24 ml/min per 1.73 m² were not investigated. This post hoc analysis retrospectively investigated eGFR decline in REPRISE versus an open-label, phase 3b extension trial (open-label extension [OLE] NCT02251275) in subjects who received placebo in REPRISE and tolvaptan in OLE with eGFR 15 to 24 and 25 to 29 ml/min per 1.73 m², respectively.

Methods

One data subset comprised subjects with OLE baseline eGFR 15 to 29 ml/min per 1.73 m² who had received placebo in REPRISE and began tolvaptan in OLE. The second compr

SUBMITTER: Torres VE 

PROVIDER: S-EPMC8343715 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature