Dataset Information

Forecasting Progressive Trends in Keratoconus by Means of a Time Delay Neural Network.

ABSTRACT: Early and accurate detection of keratoconus progression is particularly important for the prudent, cost-effective use of corneal cross-linking and judicious timing of clinical follow-up visits. The aim of this study was to verify whether a progression could be predicted based on two prior tomography measurements and to verify the accuracy of the system when labelling the eye as stable or suspect progressive. Data from 743 patients measured by Pentacam (Oculus, Wetzlar, Germany) were available, and they were filtered and preprocessed to data quality needs. The time delay neural network received six features as input, measured in two consecutive examinations, predicted the future values, and determined the classification (stable or suspect progressive) based on the significance of the change from the baseline. The system showed a sensitivity of 70.8% and a specificity of 80.6%. On average, the positive and negative predictive values were 71.4% and 80.2%. Including data of less quality (as defined by the software) did not significantly worsen the results. This predictive system constitutes another step towards a personalized management of keratoconus. While the results obtained were modest and perhaps insufficient to decide on a surgical procedure, such as cross-linking, they may be useful to customize the timing for the patient's next follow-up.

SUBMITTER: Jimenez-Garcia M

PROVIDER: S-EPMC8347247 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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Forecasting Progressive Trends in Keratoconus by Means of a Time Delay Neural Network.

Jiménez-García Marta M Issarti Ikram I Kreps Elke O EO Ní Dhubhghaill Sorcha S Koppen Carina C Varssano David D Rozema Jos J JJ

Journal of clinical medicine 20210722 15

Early and accurate detection of keratoconus progression is particularly important for the prudent, cost-effective use of corneal cross-linking and judicious timing of clinical follow-up visits. The aim of this study was to verify whether a progression could be predicted based on two prior tomography measurements and to verify the accuracy of the system when labelling the eye as stable or suspect progressive. Data from 743 patients measured by Pentacam (Oculus, Wetzlar, Germany) were available, a ...[more]

PMID: 34362023

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Project description:ObjectivesThe forecasting of horticulture commodity prices, such as bananas, has wide-ranging impacts on farmers, traders and end-users. The considerable volatility in horticultural commodities pricing estimates has allowed farmers to exploit various local marketplaces for profitable sales of their farm produce. Despite the demonstrated efficacy of machine learning models as a suitable substitute for conventional statistical approaches, their application for price forecasting in the context of Indian horticulture remains an area of contention. Past attempts to forecast agricultural commodity prices have relied on a wide variety of statistical models, each of which comes with its own set of limitations.MethodsAlthough machine learning models have emerged as formidable alternatives to more conventional statistical methods, there is still reluctance to use them for the purpose of predicting prices in India. In the present investigation, we have analysed and compared the efficacy of a variety of statistical and machine learning models in order to get accurate price forecast. Autoregressive Integrated Moving Average (ARIMA), Seasonal Autoregressive Integrated Moving Average model (SARIMA), Autoregressive Conditional Heteroscedasticity model (ARCH), Generalized Autoregressive Conditional Heteroscedasticity model (GARCH), Artificial Neural Network (ANN) and Recurrent Neural Network (RNN) were fitted to generate reliable predictions of prices of banana in Gujarat, India from January 2009 to December 2019.ResultsEmpirical comparisons have been made between the predictive accuracy of different machine learning (ML) models and the typical stochastic model and it is observed that ML approaches, especially RNN, surpassed all other models in the majority of situations. Mean Absolute Percent Error (MAPE), Root Mean Square Error (RMSE), symmetric mean absolute percentage error (SMAPE), mean absolute scaled error (MASE) and mean directional accuracy (MDA) are used to illustrate the superiority of the models and RNN resulted least in terms of all error accuracy measures.ConclusionsRNN outperforms other models in this study for predicting accurate prices when compared to various statistical and machine learning techniques. The accuracy of other methodologies like ARIMA, SARIMA, ARCH GARCH, and ANN falls short of expectations.

Dataset Information

Forecasting Progressive Trends in Keratoconus by Means of a Time Delay Neural Network.

Publications

Forecasting Progressive Trends in Keratoconus by Means of a Time Delay Neural Network.

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