Browse
Submit Data
Databases
API
Help

Dataset Information

10 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Synthesis and Characterization of Polyvinylpyrrolidone-Modified ZnO Quantum Dots and Their In Vitro Photodynamic Tumor Suppressive Action.

ABSTRACT: Despite the numerous available treatments for cancer, many patients succumb to side effects and reoccurrence. Zinc oxide (ZnO) quantum dots (QDs) are inexpensive inorganic nanomaterials with potential applications in photodynamic therapy. To verify the photoluminescence of ZnO QDs and determine their inhibitory effect on tumors, we synthesized and characterized ZnO QDs modified with polyvinylpyrrolidone. The photoluminescent properties and reactive oxygen species levels of these ZnO/PVP QDs were also measured. Finally, in vitro and in vivo experiments were performed to test their photodynamic therapeutic effects in SW480 cancer cells and female nude mice. Our results indicate that the ZnO QDs had good photoluminescence and exerted an obvious inhibitory effect on SW480 tumor cells. These findings illustrate the potential applications of ZnO QDs in the fields of photoluminescence and photodynamic therapy.

SUBMITTER: Song T

PROVIDER: S-EPMC8347431 | biostudies-literature |

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Similar Datasets

Graphene Quantum Dots Modified Upconversion Nanoparticles for Photodynamic Therapy.

Project description:Photodynamic therapy (PDT), as a novel technique, has been extensively employed in cancer treatment by utilizing reactive oxygen species (ROS) to kill malignant cells. However, most photosensitizers (PSs) are short of ROS yield and affect the therapeutic effect of PDT. Thus, there is a substantial demand for the development of novel PSs for PDT to advance its clinical translation. In this study, we put forward a new strategy for PS synthesis via modifying graphene quantum dots (GQDs) on the surface of rare-earth elements doped upconversion nanoparticles (UCNPs) to produce UCNPs@GQDs with core-shell structure. This new type of PSs combined the merits of UCNPs and GQDs and produced ROS efficiently under near-infrared light excitation to trigger the PDT process. UCNPs@GQDs exhibited high biocompatibility and obvious concentration-dependent PDT efficiency, shedding light on nanomaterials-based PDT development.

| S-EPMC9604409 | biostudies-literature

Graphene quantum dots in photodynamic therapy.

Project description:Graphene quantum dots (GQDs) have shown great promise in a variety of medical applications. Recently, it has been found that GQDs are also beneficial for photodynamic therapy (PDT). However, the findings of GQDs as PDT agents have been controversial in the literature. Herein, we investigate the photoactivity of single-atomic-layered GQDs by examining their ability to generate singlet oxygen (1O2) under irradiation and their effects on the photoactivity of photosensitizers. We demonstrate that the GQDs with lateral sizes of ∼5 or 20 nm are photo-inactive for they cannot generate 1O2 under irradiation of either a 660 nm laser (105 mW cm-2) or a halogen light. Moreover, the GQDs inhibit the photoactivity of two classical photosensitizers, namely, methylene blue and methylene violet. The stronger interaction between the GQDs and the photosensitizer results in greater inhibition of GQDs. Besides, the large-sized GQDs exhibit stronger inhibition than the small-sized GQDs. The inhibitory effect of the GQDs on the photoactivity of photosensitizers is consistent with their photo-cytotoxicity. These results indicate that the single-atomic-layered GQDs are not potential PDT agents, but they may be helpful for photosensitizers by delivering them into the cells. The discrepancy between the current work and the literature is probably associated with the GQDs used.

| S-EPMC9419651 | biostudies-literature

ZnO Nanoparticles Modified by Carbon Quantum Dots for the Photocatalytic Removal of Synthetic Pigment Pollutants.

Project description:Synthetic pigment pollutants caused by the rapid development of the modern food industry have become a serious threat to people's health and quality of life. Environmentally friendly ZnO-based photocatalytic degradation exhibits satisfactory efficiency, but some shortcomings of large band gap and rapid charge recombination reduce the removal of synthetic pigment pollutants. Here, carbon quantum dots (CQDs) with unique up-conversion luminescence were applied to decorate ZnO nanoparticles to effectively construct the CQDs/ZnO composites via a facile and efficient route. The ZnO nanoparticles with a spherical-like shape obtained from a zinc-based metal organic framework (zeolitic imidazolate framework-8, ZIF-8) were coated by uniformly dispersive quantum dots. Compared with single ZnO particles, the obtained CQDs/ZnO composites exhibit enhanced light absorption capacity, decreased photoluminescence (PL) intensity, and improved visible-light degradation for rhodamine B (RhB) with the large apparent rate constant (k app). The largest k app value in the CQDs/ZnO composite obtained from 75 mg of ZnO nanoparticles and 12.5 mL of the CQDs solution (∼1 mg·mL-1) was 2.6 times that in ZnO nanoparticles. This phenomenon may be attributed to the introduction of CQDs, leading to the narrowed band gap, an extended lifetime, and the charge separation. This work provides an economical and clean strategy to design visible-light-responsive ZnO-based photocatalysts, which is expected to be used for the removal of synthetic pigment pollutants in food industry.

| S-EPMC9979235 | biostudies-literature

ZnO Quantum Dots Modified by pH-Activated Charge-Reversal Polymer for Tumor Targeted Drug Delivery.

Project description:In this paper, we reported a pH responsive nano drug delivery system (NDDS) based on ZnO quantum dots (QDs) for controlled release of drugs. Zwitterionic poly(carboxybetaine methacrylate) (PCBMA) and poly(2-(dimethylamino) ethyl methacrylate) (PDMAEMA) were introduced to modify ZnO QDs, which can help enhance water stability, increase blood circulation time, and promote endocytosis. After tuning of PCBMA/PDMAEMA ratios, the ZnO@P(CBMA-co-DMAEMA) nanoplatform shows a sensitive switch from strong protein adsorption resistance (with negatively charged surface) at physiological pH to strong adhesion to tumor cell membranes (with positively charged surface) at the slightly acidic extracellular pH of tumors. Anti-cancer drug, Doxorubicin (DOX), molecules were demonstrated to be successfully loaded to ZnO@P(CBMA-co-DMAEMA) with a relatively large drug loading content (24.6%). In addition, ZnO@P(CBMA-co-DMAEMA) loaded with DOX can achieve lysosomal acid degradation and release of DOX after endocytosis by tumor cells, resulting in synergistic treatment of cancer, which is attributed to a combination of the anticancer effect of Zn2+ and DOX.

| S-EPMC6401959 | biostudies-literature

Enhanced Luminance of CdSe/ZnS Quantum Dots Light-Emitting Diodes Using ZnO-Oleic Acid/ZnO Quantum Dots Double Electron Transport Layer.

Project description:The widely used ZnO quantum dots (QDs) as an electron transport layer (ETL) in quantum dot light-emitting diodes (QLEDs) have one drawback. That the balancing of electrons and holes has not been effectively exploited due to the low hole blocking potential difference between the valence band (VB) (6.38 eV) of ZnO ETL and (6.3 eV) of CdSe/ZnS QDs. In this study, ZnO QDs chemically reacted with capping ligands of oleic acid (OA) to decrease the work function of 3.15 eV for ZnO QDs to 2.72~3.08 eV for the ZnO-OA QDs due to the charge transfer from ZnO to OA ligands and improve the efficiency for hole blocking as the VB was increased up to 7.22~7.23 eV. Compared to the QLEDs with a single ZnO QDs ETL, the ZnO-OA/ZnO QDs double ETLs optimize the energy level alignment between ZnO QDs and CdSe/ZnS QDs but also make the surface roughness of ZnO QDs smoother. The optimized glass/ITO/PEDOT:PSS/PVK//CdSe/ZnS//ZnO-OA/ZnO/Ag QLEDs enhances the maximum luminance by 5~9% and current efficiency by 16~35% over the QLEDs with a single ZnO QDs ETL, which can be explained in terms of trap-charge limited current (TCLC) and the Fowler-Nordheim (F-N) tunneling conduction mechanism.

| S-EPMC9231060 | biostudies-literature

RAFT Hydroxylated Polymers as Templates and Ligands for the Synthesis of Fluorescent ZnO Quantum Dots

Project description:The remarkable photoluminescent properties, biocompatibility, biodegradability, and antibacterial properties of zinc oxide quantum dots (ZnO QDs) coupled with their low cost and nanoscale size guarantee bio-related and technological applications. However, the effect of the polymeric ligand during synthesis has hardly been investigated compared to other less environmentally friendly QDs. Thus, the objective of this work was to focus on the synthesis of fluorescent hybrid ZnO QDs by the sol-gel method using different polymers with hydroxyl groups as templates and ligands to obtain stable particles in different media. For this purpose, well-defined hydroxylated statistical polymers and block copolymers were synthesized using reversible-addition fragmentation chain transfer (RAFT) polymerization to establish the influence of molecular weight, hydrophobic/hydrophilic balance, and polymer architecture on the colloidal and photophysical properties of the synthesized hybrid ZnO QDs. Dynamic light scattering (DLS), TEM, and X-ray diffraction measurements indicated the formation of stable nanoparticles of a few nanometers. A remarkable enhancement in terms of fluorescence was observed when ZnO QDs were synthesized in the presence of the hydroxylated homopolymers and even more so with block copolymers architecture. Organosilanes combined with the hydroxylated polymers were used to improve the colloidal stability of ZnO QDs in aqueous media. These samples exhibited uniform and stable enhanced photoluminescence for nearly five months of being investigated. Among other applications, the hybrid ZnO QDs synthesized in this work exhibit high selectivity to detect Cr6+, Fe2+, or Cu2+ in water.

| S-EPMC9565916 | biostudies-literature

Dose-Dependent Effect of ZnO Quantum Dots for Lettuce Growth.

Project description:As the cadmium-free semiconductor quantum dots, ZnO quantum dots (ZnO QDs) have wide potential applications in agriculture. However, the effects of ZnO quantum dots on crop growth and nutritional quality have not been fully studied. In this work, the lettuce was sprayed with different concentrations of ZnO QDs from 50 to 500 mg·L-1 to evaluate their influence on lettuce antioxidant, biomass, and nutritional quality. The results showed that ZnO QDs existed in the lettuce in the form of Zn2+. Lettuce treated with 500 mg·L-1 ZnO QDs would produce a large amount of reactive oxygen species (ROS), which adversely affected the absorption of nutrients, soluble protein content, and chlorophyll content, thus reducing plant biomass. When the concentrations range from 50 to 200 mg·L-1, the antioxidant enzyme systems of lettuce were triggered to counteract the damage caused by excessive ROS. Moreover, ZnO QDs at this level promoted Ca, Mg, Fe, Mn, Zn, and B absorption and accumulation; increased soluble sugar content; and improved the lettuce biomass and nutritional quality.

| S-EPMC8153660 | biostudies-literature

Synthesis of ZnxCd1-xSe@ZnO Hollow Spheres in Different Sizes for Quantum Dots Sensitized Solar Cells Application.

Project description:ZnxCd1-xSe@ZnO hollow spheres (HS) were successfully fabricated for application in quantum dot sensitized solar cells (QDSSCs) based on ZnO HS through the ion-exchange process. The sizes of the ZnxCd1-xSe@ZnO HS could be tuned from ~300 nm to ~800 nm using ZnO HS pre-synthesized by different sizes of carbonaceous spheres as templates. The photovoltaic performance of QDSSCs, especially the short-circuit current density (Jsc), experienced an obvious change when different sizes of ZnxCd1-xSe@ZnO HS are employed. The ZnxCd1-xSe@ZnO HS with an average size distribution of ~500 nm presented a better performance than the QDSSCs based on other sizes of ZnxCd1-xSe@ZnO HS. When using the mixture of ZnxCd1-xSe@ZnO HS with different sizes, the power conversion efficiency can be further improved. The size effect of the hollow spheres, light scattering, and composition gradient structure ZnxCd1-xSe@ZnO HS are responsible for the enhancement of the photovoltaic performance.

| S-EPMC6410306 | biostudies-literature

Transcriptome Profile of Quantum Dots on Saccharomyces cerevisiae

Project description:Transcriptome Profile of CdSe/ZnS and InP/ZnS Quantum Dots on Saccharomyces cerevisiae

2021-01-30 | GSE165805 | GEO

Polyvinylpyrrolidone-passivated fluorescent iron oxide quantum dots for turn-off detection of tetracycline in biological fluids.

Project description:Tetracycline is an antibiotic that has been prescribed for COVID-19 treatment, raising concerns about antibiotic resistance after long-term use. This study reported fluorescent polyvinylpyrrolidone-passivated iron oxide quantum dots (IO QDs) for detecting tetracycline in biological fluids for the first time. The as-prepared IO QDs have an average size of 2.84 nm and exist a good stability under different conditions. The IO QDs' tetracycline detection performance could be attributed to a combination of static quenching and inner filter effect. The IO QDs displayed high sensitivity and selectivity toward tetracycline and achieved a good linear relationship with the corresponding detection limit being 91.6 nM.

| S-EPMC10208663 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data