Unknown

Dataset Information

0

Detecting and Profiling Endogenous RNA G-Quadruplexes in the Human Transcriptome.


ABSTRACT: G-quadruplexes are the non-canonical nucleic acid structures that are preferentially formed in G-rich regions. This structure has been shown to be associated with many biological functions. Regardless of the broad efforts on DNA G-quadruplexes, we still have limited knowledge on RNA G-quadruplexes, especially in a transcriptome-wide manner. Herein, by integrating the DMS-seq and the bioinformatics pipeline, we profiled and depicted the RNA G-quadruplexes in the human transcriptome. The genes that contain RNA G-quadruplexes in their specific regions are significantly related to immune pathways and the COVID-19-related gene sets. Bioinformatics analysis reveals the potential regulatory functions of G-quadruplexes on miRNA targeting at the scale of the whole transcriptome. In addition, the G-quadruplexes are depleted in the putative, not the real, PAS-strong poly(A) sites, which may weaken the possibility of such sites being the real cleaved sites. In brief, our study provides insight into the potential function of RNA G-quadruplexes in post-transcription.

SUBMITTER: Zhang R 

PROVIDER: S-EPMC8347560 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC6226477 | biostudies-literature
| S-EPMC3594279 | biostudies-literature
| S-EPMC8064279 | biostudies-literature
| S-EPMC5499804 | biostudies-other
| S-EPMC7671396 | biostudies-literature
| S-EPMC6917696 | biostudies-literature
| S-EPMC5819366 | biostudies-literature
| S-EPMC6420650 | biostudies-literature
| S-EPMC4208030 | biostudies-literature
| S-EPMC7283149 | biostudies-literature