Serine-Selective Bioconjugation.
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ABSTRACT: This Communication reports the first general method for rapid, chemoselective, and modular functionalization of serine residues in native polypeptides, which uses a reagent platform based on the P(V) oxidation state. This redox-economical approach can be used to append nearly any kind of cargo onto serine, generating a stable, benign, and hydrophilic phosphorothioate linkage. The method tolerates all other known nucleophilic functional groups of naturally occurring proteinogenic amino acids. A variety of applications can be envisaged by this expansion of the toolbox of site-selective bioconjugation methods.
SUBMITTER: Vantourout JC
PROVIDER: S-EPMC8350984 | biostudies-literature |
REPOSITORIES: biostudies-literature
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