Serine-Selective Bioconjugation.
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ABSTRACT:
SUBMITTER: Vantourout JC
PROVIDER: S-EPMC8350984 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Publications
Serine-Selective Bioconjugation.
Vantourout Julien C JC Adusumalli Srinivasa Rao SR Knouse Kyle W KW Flood Dillon T DT Ramirez Antonio A Padial Natalia M NM Istrate Alena A Maziarz Katarzyna K deGruyter Justine N JN Merchant Rohan R RR Qiao Jennifer X JX Schmidt Michael A MA Deery Michael J MJ Eastgate Martin D MD Dawson Philip E PE Bernardes Gonçalo J L GJL Baran Phil S PS
Journal of the American Chemical Society 20201005 41
This Communication reports the first general method for rapid, chemoselective, and modular functionalization of serine residues in native polypeptides, which uses a reagent platform based on the P(V) oxidation state. This redox-economical approach can be used to append nearly any kind of cargo onto serine, generating a stable, benign, and hydrophilic phosphorothioate linkage. The method tolerates all other known nucleophilic functional groups of naturally occurring proteinogenic amino acids. A v ...[more]
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