Ontology highlight
ABSTRACT:
SUBMITTER: Weng Y
PROVIDER: S-EPMC9643349 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Weng Yue Y Su Chun-Jen CJ Jiang Haoyang H Chiang Chien-Wei CW
Scientific reports 20221108 1
Site-selectively chemical bioconjugation of peptides and proteins can improve the therapeutic exploration of modified protein drugs. Only 3.8% natural abundance of phenylalanine in protein and nearly 90% of proteins contain at least one phenylalanine residue in their sequenced, showing the potential in biopharmaceutical utility of the phenylalanine bioconjugation. However, the covalent bioconjugation of native phenylalanine is one of the most challenging problems in protein modification. Herein, ...[more]