Home infusions of natalizumab for people with multiple sclerosis: a pilot randomised crossover trial.

ABSTRACT:

Objective

The delivery of healthcare at home has expanded to intravenous infusions of monoclonal antibodies. A recently developed model of care for home infusions of natalizumab for people with relapsing-remitting multiple sclerosis was evaluated. This pilot study of home infusions of natalizumab and usual care (attendance in a hospital out-patients' clinic) compared safety, feasibility, patient satisfaction, effectiveness and costs.

Methods

In this randomised AB/BA crossover trial, 37 adults were randomised to usual care (n = 19) or home infusions (n = 18). After three infusions, patients crossed over to the alternate treatment for another three infusions. Patient safety outcomes and adherence, satisfaction, quality of life, disability and costs were compared.

Results

SUBMITTER: Schultz TJ 

PROVIDER: S-EPMC8351394 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature