Unknown

Dataset Information

0

The ability of continuous-wave Doppler ultrasound to detect fetal growth restriction.


ABSTRACT:

Background

Fetal growth restriction (FGR), defined as a fetus failing to reach its genetic growth potential, remains poorly diagnosed antenatally. This study aimed to assess the ability of continuous-wave Doppler ultrasound of the umbilical artery (CWD-UmA) to detect FGR in healthy women with low-risk pregnancies.

Methods and findings

This prospective longitudinal descriptive cohort study enrolled infants born to low-risk mothers who were screened with CWD-UmA between 28-34 weeks' gestation; the resistance index (RI) was classified as normal or abnormal. Infants were assessed at 6, 10, 14 weeks, and 6 months postnatally for anthropometric indicators and body composition using the deuterium dilution method to assess fat-free mass (FFM). Neonates in the abnormal RI group were compared with those in the normal RI group, and neonates classified as small-for-gestational age (SGA) were compared with appropriate-for-gestational age (AGA) neonates. Eighty-one term infants were included. Only 6 of 26 infants (23.1%) with an abnormal RI value would have been classified as SGA. The abnormal RI group had significantly reduced mean FFM and FFM-for-age Z-scores at 6, 10, 14 weeks, and 6 months compared with the normal RI group (P<0.015). The SGA group's FFM did not show this consistent trend when compared to AGA FFM, being significantly different only at 6 months (P = 0.039). The main limitation of the study was the small sample size of the infant follow-up.

Conclusions

Abnormal RI obtained from CWD-UmA is able to detect FGR and is considered a useful addition to classifying the neonate only by SGA or AGA at birth.

SUBMITTER: Feucht U 

PROVIDER: S-EPMC8351973 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC10223844 | biostudies-literature
| S-EPMC8848397 | biostudies-literature
| S-EPMC8351928 | biostudies-literature
| S-EPMC3276538 | biostudies-literature
| S-EPMC8360092 | biostudies-literature
| S-EPMC8243629 | biostudies-literature
| S-EPMC9562243 | biostudies-literature
| S-EPMC10769912 | biostudies-literature
| S-EPMC9313890 | biostudies-literature
| S-EPMC7885360 | biostudies-literature