Direct in vivo assessment of global and regional mechanoelectric feedback in the intact human heart.

ABSTRACT:

Background

Inhomogeneity of ventricular contraction is associated with sudden cardiac death, but the underlying mechanisms are unclear. Alterations in cardiac contraction impact electrophysiological parameters through mechanoelectric feedback. This has been shown to promote arrhythmias in experimental studies, but its effect in the in vivo human heart is unclear.

Objective

The purpose of this study was to quantify the impact of regional myocardial deformation provoked by a sudden increase in ventricular loading (aortic occlusion) on human cardiac electrophysiology.

Methods

In 10 patients undergoing open heart cardiac surgery, left ventricular (LV) afterload was modified by transient aortic occlusion. Simultaneous assessment of whole-heart electrophysiology and LV defo

SUBMITTER: Orini M 

PROVIDER: S-EPMC8353585 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature