Ontology highlight
ABSTRACT:
SUBMITTER: Byers B
PROVIDER: S-EPMC5573170 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Byers Blake B Lee Hyun Joo HJ Liu Jia J Weitz Andrew J AJ Lin Peter P Zhang Pengbo P Shcheglovitov Aleksandr A Dolmetsch Ricardo R Pera Renee Reijo RR Lee Jin Hyung JH
NeuroImage 20150425
Despite the potential of stem cell-derived neural transplants for treating intractable neurological diseases, the global effects of a transplant's electrical activity on host circuitry have never been measured directly, preventing the systematic optimization of such therapies. Here, we overcome this problem by combining optogenetics, stem cell biology, and neuroimaging to directly map stem cell-driven neural circuit formation in vivo. We engineered human induced pluripotent stem cells (iPSCs) to ...[more]