Identification of COVID-19 and Dengue Host Factor Interaction Networks Based on Integrative Bioinformatics Analyses.

ABSTRACT:

Background

The outbreak of Coronavirus disease 2019 (COVID-19) has become an international public health crisis, and the number of cases with dengue co-infection has raised concerns. Unfortunately, treatment options are currently limited or even unavailable. Thus, the aim of our study was to explore the underlying mechanisms and identify potential therapeutic targets for co-infection.

Methods

To further understand the mechanisms underlying co-infection, we used a series of bioinformatics analyses to build host factor interaction networks and elucidate biological process and molecular function categories, pathway activity, tissue-specific enrichment, and potential therapeutic agents.

Results

We explored the pathologic mechanisms of COVID-19 and dengue co-infection, inc

SUBMITTER: Zheng W 

PROVIDER: S-EPMC8356054 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature