Browse
Submit Data
Databases
API
Help

Dataset Information

25 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

[How does COVID-19 affect intestinal microbiota?]

ABSTRACT:

Background

There is a bidirectional interaction between the intestines and lungs, the so-called lung-intestinal axis.

Method

The review article reports on studies that deal with a possible influence of the intestinal microbiota on the immune response to a SARS-CoV-2 infection.

Results and conclusions

Studies have shown that COVID-19 is accompanied by dysbiosis that persists even after successful virus conversion (negative PCR). One study found that the severity of COVID-19 is associated with the intestinal microbiota. A dysbiosis could thus favor the so-called cytokine storm. There is indication that pre- and probiotics could boost the immune response in both the guts and lungs.

SUBMITTER: Konturek PC

PROVIDER: S-EPMC8359639 | biostudies-literature |

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Similar Datasets

Human gut microbiota, COVID-19 patients with mild or severe symptoms.

Project description:Analysis of COVID-19 hospitalized patients, with different kind of symptoms, by human rectal swabs collection and 16S sequencing approach.

2022-09-22 | E-MTAB-12236 | biostudies-arrayexpress

COVID-19 gut microbiota

Project description:Gut microbiota in patients with COVID-19 in Ireland

| PRJEB55910 | ENA

The intestinal microbiota and improving the efficacy of COVID-19 vaccinations.

Project description:Most COVID-19 cases are mild or asymptomatic and recover well, suggesting that effective immune responses ensue, which successfully eliminate SARS-CoV-2 viruses. However, a small proportion of patients develop severe COVID-19 with pathological immune responses. This indicates that a strong immune system balanced with anti-inflammatory mechanisms is critical for the recovery from SARS-CoV-2 infections. Many vaccines against SARS-CoV-2 have now been developed for eliciting effective immune responses to protect from SARS-CoV-2 infections or reduce the severity of the disease if infected. Although uncommon, serious morbidity and mortality have resulted from both COVID-19 vaccine adverse reactions and lack of efficacy, and further improvement of efficacy and prevention of adverse effects are urgently warranted. Many factors could affect efficacy of these vaccines to achieve optimal immune responses. Dysregulation of the gut microbiota (gut dysbiosis) could be an important risk factor as the gut microbiota is associated with the development and maintenance of an effective immune system response. In this narrative review, we discuss the immune responses to SARS-CoV-2, how COVID-19 vaccines elicit protective immune responses, gut dysbiosis involvement in inefficacy and adverse effects of COVID-19 vaccines and the modulation of the gut microbiota by functional foods to improve COVID-19 vaccine immunisations.

| S-EPMC8578005 | biostudies-literature

COVID - 19 and Advanced Gastro-intestinal Cancer Treatment

Project description:A multicenter Italian retrospective study on COVID-19 pandemic condition and advanced Gastro - Intestinal Cancer. Are in Italy increased the new diagnosis of GI cancer in advanced stage in the 2020 compared with 2019, as a consequence of COVID-19?

| 2362155 | ecrin-mdr-crc

Cohort survey of healthcare workers with COVID-19 infection

Project description: Not available

| S-BSST563 | biostudies-other

Antibiotics affect the pharmacokinetics of n-butylphthalide in vivo by altering the intestinal microbiota

Project description: Not available

| S-BSST1443 | biostudies-other

Does Temperature Affect COVID-19 Transmission?

Project description:This study utilizes the non-linear least squares method to estimate the impact of temperature on COVID-19 cases per million in forty-three countries, divided into three groups as follows: the first group is composed of thirteen countries that announced the first COVID-19 cases in January 2020, while the second and third groups contain thirteen and seventeen countries, respectively, that witnessed the pandemic for the first time in February and March of the same year. This relationship was measured after four time periods from the date of reporting the first case until April 1, April 15, May 15, and July 8, 2020. The results show an inverse relationship between COVID-19 cases per million and the temperature in the studies of the four-time periods for the three-country groups. These results were only significant statistically (p < 0.1) after 110.8, 164.8 days on average from the beginning of the pandemic in the case of "January" countries.

| S-EPMC7793668 | biostudies-literature

Proteomic blood profiling in mild, severe and critical COVID-19 patients

Project description: Not available

| S-BSST416 | biostudies-other

How does COVID-19 vaccination affect long-COVID symptoms?

Project description:ObjectiveThe current study aimed to identify the association between COVID-19 vaccination and prolonged post-COVID symptoms (long-COVID) in adults who reported suffering from this condition.MethodsThis was a retrospective follow-up study of adults with long-COVID syndrome. The data were collected during a phone call to the participants in January-February 2022. We inquired about their current health status and also their vaccination status if they agreed to participate.ResultsIn total, 1236 people were studied; 543 individuals reported suffering from long long- COVID (43.9%). Chi square test showed that 15 out of 51 people (29.4%) with no vaccination and 528 out of 1185 participants (44.6%) who received at least one dose of any vaccine had long long- COVID symptoms (p = 0.032).ConclusionsIn people who have already contracted COVID-19 and now suffer from long-COVID, receiving a COVID vaccination has a significant association with prolonged symptoms of long-COVID for more than one year after the initial infection. However, vaccines reduce the risk of severe COVID-19 (including reinfections) and its catastrophic consequences (e.g., death). Therefore, it is strongly recommended that all people, even those with a history of COVID-19, receive vaccines to protect themselves against this fatal viral infection.

| S-EPMC10849259 | biostudies-literature

Covid-19

Project description:Host

| PRJEB62576 | ENA