Cardio-metabolic risk factors during childhood in relation to lung function and asthma.

ABSTRACT:

Background

Cardio-metabolic risk factors might have an adverse effect on respiratory outcomes, but associations in children are unknown. We aimed to study the longitudinal associations of cardio-metabolic risk factors with lung function and asthma at school age. We also examined whether any association was explained by child's body mass index (BMI).

Methods

In a population-based cohort study among 4988 children, cardio-metabolic risk factors were measured at 6 and 10 years and included blood pressure, cholesterol, triglycerides, insulin, and C-reactive protein (CRP) concentrations. At age 10 years, lung function was measured by spirometry and current physician-diagnosed asthma was assessed by questionnaire.

Results

After adjustment for confounders, child's BMI, and mu

SUBMITTER: Mensink-Bout SM 

PROVIDER: S-EPMC8360082 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature