Ontology highlight
ABSTRACT:
SUBMITTER: Guo Y
PROVIDER: S-EPMC8362028 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Guo Yafang Y Baschieri Andrea A Mollica Fabio F Valgimigli Luca L Cedrowski Jakub J Litwinienko Grzegorz G Amorati Riccardo R
Angewandte Chemie (International ed. in English) 20210604 28
Melanins are stable and non-toxic biomaterials with a great potential as chemopreventive agents for diseases connected with oxidative stress, but the mechanism of their antioxidant action is unclear. Herein, we show that polydopamine (PDA), a well-known synthetic melanin, becomes an excellent trap for alkylperoxyl radicals (ROO<sup>.</sup> , typically formed during autoxidation of lipid substrates) in the presence of hydroperoxyl radicals (HOO<sup>.</sup> ). The key reaction explaining this pecu ...[more]