Sparse precontrast T₁ mapping for high-resolution whole-brain DCE-MRI.

ABSTRACT:

Purpose

To develop and evaluate an efficient precontrast T₁ mapping technique suitable for quantitative high-resolution whole-brain dynamic contrast-enhanced-magnetic resonance imaging (DCE-MRI).

Methods

Variable flip angle (VFA) T₁ mapping was considered that provides 1 × 1 × 2 mm³ resolution to match a recent high-resolution whole-brain DCE-MRI protocol. Seven FAs were logarithmically spaced from 1.5° to 15°. T₁ and M₀ maps were estimated using model-based reconstruction. This approach was evaluated using an anatomically realistic brain tumor digital reference object (DRO) with noise-mimicking 3T neuroimaging and fully sampled data acquired from one healthy volunteer. Methods were also applied on fourfold prospectively

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC8362109 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature