Cis-regulatory variants affect gene expression dynamics in yeast.

ABSTRACT: Evolution of cis-regulatory sequences depends on how they affect gene expression and motivates both the identification and prediction of cis-regulatory variants responsible for expression differences within and between species. While much progress has been made in relating cis-regulatory variants to expression levels, the timing of gene activation and repression may also be important to the evolution of cis-regulatory sequences. We investigated allele-specific expression (ASE) dynamics within and between Saccharomyces species during the diauxic shift and found appreciable cis-acting variation in gene expression dynamics. Within-species ASE is associated with intergenic variants, and ASE dynamics are more strongly associated with insertions and deletions than ASE levels. To refine these ass

SUBMITTER: Shih CH 

PROVIDER: S-EPMC8367379 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature