Ontology highlight
ABSTRACT:
SUBMITTER: Kumar P
PROVIDER: S-EPMC8371023 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Kumar Parameet P Soni Dharmendra Kumar DK Sen Chaitali C Larsen Mads B MB Mazan-Mamczarz Krystyna K Piao Yulan Y De Supriyo S Gorospe Myriam M Frizzell Raymond A RA Biswas Roopa R
Scientific reports 20210817 1
Cystic fibrosis (CF) occurs as a result of mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which lead to misfolding, trafficking defects, and impaired function of the CFTR protein. Splicing factor proline/glutamine-rich (SFPQ) is a multifunctional nuclear RNA-binding protein (RBP) implicated in the regulation of gene expression pathways and intracellular trafficking. Here, we investigated the role of SFPQ in the regulation of the expression and function of F508d ...[more]