Unknown

Dataset Information

0

Photoacoustic Force-Guided Precise and Fast Delivery of Nanomedicine with Boosted Therapeutic Efficacy.


ABSTRACT: Precise and efficient delivery of nanomedicine to the target site has remained as a major roadblock in advanced cancer treatment. Here, a novel photoacoustic force (PAF)-guided nanotherapeutic system is reported based on a near-infrared (NIR)-absorbing semiconducting polymer (SP), showing significantly improved tumor accumulation and deep tissue penetration for enhanced phototherapeutic efficacy. The accumulation of nanoparticles in 4T1 tumor-bearing mice induced by the PAF strategy displays a fivefold enhancement in comparison with that of the traditional passive targeting pathway, in a significantly shortened time (45 min vs 24 h) with an enhanced penetration depth in tumors. Additionally, a tumor-bearing mouse model is rationally designed to unveil the mechanism, indicating that the nanoparticles enter solid tumors through enhanced transportation across blood vessel barriers via both inter-endothelial gaps and active trans-endothelial pathways. This process is specifically driven by PAF generated from the nanoparticles under NIR laser irradiation. The study thus demonstrates a new nanotherapeutic strategy with low dose, enhanced delivery efficiency in tumor, and boosted therapeutic efficacy, opening new doors for designing novel nanocarriers.

SUBMITTER: Wang J 

PROVIDER: S-EPMC8373104 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC7582572 | biostudies-literature
| S-EPMC6435337 | biostudies-literature
| S-EPMC5995140 | biostudies-literature
| S-EPMC5462466 | biostudies-literature
| S-EPMC9691371 | biostudies-literature
| S-EPMC6013461 | biostudies-literature
| S-EPMC5523511 | biostudies-literature
| S-EPMC6748954 | biostudies-literature
| S-EPMC5803551 | biostudies-literature
2022-01-08 | GSE189482 | GEO