Potential effects of mesenchymal stem cell derived extracellular vesicles and exosomal miRNAs in neurological disorders.

ABSTRACT: Mesenchymal stem cells are multipotent cells that possess anti-inflammatory, anti-apoptotic and immunomodulatory properties. The effects of existing drugs for neurodegenerative disorders such as Alzheimer's disease are limited, thus mesenchymal stem cell therapy has been anticipated as a means of ameliorating neuronal dysfunction. Since mesenchymal stem cells are known to scarcely differentiate into neuronal cells in damaged brain after transplantation, paracrine factors secreted from mesenchymal stem cells have been suggested to exert therapeutic effects. Extracellular vesicles and exosomes are small vesicles released from mesenchymal stem cells that contain various molecules, including proteins, mRNAs and microRNAs. In recent years, administration of exosomes/extracellular vesicles in mo

SUBMITTER: Nakano M 

PROVIDER: S-EPMC8374551 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature