Ontology highlight
ABSTRACT:
SUBMITTER: Rui J
PROVIDER: S-EPMC8379260 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Rui Jinxiu J Deng Songyan S Perdigoto Ana Luisa AL Ponath Gerald G Kursawe Romy R Lawlor Nathan N Sumida Tomokazu T Levine-Ritterman Maya M Stitzel Michael L ML Pitt David D Lu Jun J Herold Kevan C KC
Nature communications 20210820 1
β cells may participate and contribute to their own demise during Type 1 diabetes (T1D). Here we report a role of their expression of Tet2 in regulating immune killing. Tet2 is induced in murine and human β cells with inflammation but its expression is reduced in surviving β cells. Tet2-KO mice that receive WT bone marrow transplants develop insulitis but not diabetes and islet infiltrates do not eliminate β cells even though immune cells from the mice can transfer diabetes to NOD/scid recipient ...[more]