Secretome signature of cardiopoietic cells echoed in rescued infarcted heart proteome.
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ABSTRACT:
SUBMITTER: Arrell DK
PROVIDER: S-EPMC8380441 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Publications
Secretome signature of cardiopoietic cells echoed in rescued infarcted heart proteome.
Arrell D Kent DK Crespo-Diaz Ruben J RJ Yamada Satsuki S Jeon Ryounghoon R Garmany Armin A Park Sungjo S Adolf Jeffrey P JP Livia Christopher C Hillestad Matthew L ML Bartunek Jozef J Behfar Atta A Terzic Andre A
Stem cells translational medicine 20210528 9
Stem cell paracrine activity is implicated in cardiac repair. Linkage between secretome functionality and therapeutic outcome was here interrogated by systems analytics of biobanked human cardiopoietic cells, a regenerative biologic in advanced clinical trials. Protein chip array identified 155 proteins differentially secreted by cardiopoietic cells with clinical benefit, expanded into a 520 node network, collectively revealing inherent vasculogenic properties along with cardiac and smooth muscl ...[more]
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