Nanoparticles targeting the infarcted heart.
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ABSTRACT:
SUBMITTER: Dvir T
PROVIDER: S-EPMC3192253 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Publications
Nanoparticles targeting the infarcted heart.
Dvir Tal T Bauer Michael M Schroeder Avi A Tsui Jonathan H JH Anderson Daniel G DG Langer Robert R Liao Ronglih R Kohane Daniel S DS
Nano letters 20110914 10
We report a nanoparticulate system capable of targeting the heart after myocardial infarction (MI). Targeting is based on overexpression of angiotensin II type 1 (AT1) receptor in the infarcted heart. Liposomes 142 nm in diameter were conjugated with a ligand specific to AT1. The nanoparticles were able to specifically target cardiac cells in vitro, and in the infarcted heart after intravenous injection in vivo. This system may be useful for delivering therapeutic agents specifically to the infa ...[more]
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