ADHD and depression: investigating a causal explanation.

ABSTRACT:

Background

Attention-deficit hyperactivity disorder (ADHD) is associated with later depression and there is considerable genetic overlap between them. This study investigated if ADHD and ADHD genetic liability are causally related to depression using two different methods.

Methods

First, a longitudinal population cohort design was used to assess the association between childhood ADHD (age 7 years) and recurrent depression in young-adulthood (age 18-25 years) in N = 8310 individuals in the Avon Longitudinal Study of Parents and Children (ALSPAC). Second, two-sample Mendelian randomization (MR) analyses examined relationships between genetic liability for ADHD and depression utilising published Genome-Wide Association Study (GWAS) data.

Results

Childhood ADHD was associ

SUBMITTER: Riglin L 

PROVIDER: S-EPMC8381237 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature