Ontology highlight
ABSTRACT:
SUBMITTER: Moons SJ
PROVIDER: S-EPMC8382218 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Moons Sam J SJ Rossing Emiel E Heming Jurriaan J A JJA Janssen Mathilde A C H MACH van Scherpenzeel Monique M Lefeber Dirk J DJ de Jonge Marien I MI Langereis Jeroen D JD Boltje Thomas J TJ
Bioconjugate chemistry 20210527 6
Bacterial pathogens such as Nontypeable <i>Haemophilus influenzae</i> (NTHi) can evade the immune system by taking up and presenting host-derived sialic acids. Herein, we report a detailed structure-activity relationship of sialic acid-based inhibitors that prevent the transfer of host sialic acids to NTHi. We report the synthesis and biological evaluation of C-5, C-8, and C-9 derivatives of the parent compound 3-fluorosialic acid (SiaNFAc). Small modifications are tolerated at the C-5 and C-9 p ...[more]